The　action　potential　across　biological　membranes　formed　by　osmotic　gradient　induced　by　external　conditions　plays　a　key　role　in　the　signal　transmission　of　life　processes,　which　can　inspire　researchers　to　develop　artificial　osmotic　power　generation　device　with　multi-stimuli　controllable　power　output.　Herein,　an　adaptive　2D　nanochannel　membrane　is　fabricated　by　stacking　of　montmorillonite　nanosheets　co-modified　with　a　laboratory　synthesized　cationic　surfactant　containing　spiropyran　species　and　a　commercially　cationic　surfactant　of　dioctadecyldimethylammonium　bromide.　Similar　to　biological　action　potentials,　the　osmotic　power　generation　of　2D　nanochannel　membranes　can　be　regulated　by　external　multiple　stimuli　such　as　light,　pH　and　temperature　based　on　the　adaptive　ion　selectivity　and　ion　flux　of　nanofluidic　channels　relying　on　the　surface　charges　of　spiropyran　species　and　the　phase　state　of　surfactants.　Impressively,　the　control　of　temperature　rising　to　60　degrees　C　significantly　boosted　the　maximum　power　density　of　2D　nanochannel　membrane　from　similar　to　0.81　W/m(2)　to　be　similar　to　7.12　W/m(2)　by　8.8　times　at　a　gradient　of　artificial　sea　water　and　river　water　resulting　from　the　enhanced　ion　flux　by　phase　transition　of　surfactants,　which　is　the　highest　value　among　those　of　clay-based　nanochannel　membranes　and　ion　exchange　membranes.　Our　results　implies　that　the　development　of　adaptive　2D　nanochannel　membranes　is　a　new　strategy　for　improving　the　power　output　of　osmotic　energy　conversion　devices.