In　this　paper,　a　new　life　assessment　framework　is　proposed　based　on　the　elastic-viscoplastic　modeling　and　the　damage　behavior　for　the　structural　component　under　multiaxial　nonproportional　loading　at　high　temperature.　The　viscoplastic　constitutive　model　with　the　ability　to　capture　the　non-proportional　hardening　effect　is　used　to　obtain　the　stress-strain　fields,　in　which　a　new　method　based　on　the　rotation　of　strain　axis　is　proposed　to　evaluate　the　notch　rotation　factor.　The　damage　model,　which　can　comprehensively　capture　the　multiaxial　fatigue-oxidationcreep　behaviors,　is　used　to　assess　the　failure　life.　In　addition,　the　proposed　framework　is　evaluated　by　the　life　results　under　proportional　and　non-proportional　fatigue　loadings　at　650　degrees　C,　and　the　errors　are　found　to　be　within　a　factor　of　2.