A　novel　simultaneous　partial　nitrification,　endogenous　denitrification　and　phosphorus　removal　(SPNEDpr)　system　was　operated　for　213　days　in　a　sequencing　batch　reactor　to　treat　real　domestic　sewage.　The　nutrient　removal　was　achieved　under　an　operation　mode　of　intermittent　aeration　at　unequal　intervals　with　low　oxygen　concentrations.　Through　optimizing　intermittent　aeration　conditions,　the　removal　efficiencies　of　total　inorganic　nitrogen　(TIN),　PO43-P　and　chemical　oxygen　demand　(COD)　reached　78.40%,　98.13%　and　84%,　respectively.　Low　oxygen　(0.1-0.7　mg/L)　and　intermittent　aeration　effectively　inhibited　nitrite　oxidation　bacteria　(NOB),　maintaining　stable　partial　nitrification　with　nitrite　accumulation　ratio　of　96.45%.　Notably,　intermittent　aeration　promoted　the　formation　of　aerobic　granular　sludge,　with　the　sludge　particle　size　increasing　from　217.2　+/-　5.3　to　351.8　+/-　4.8　mu　m,　thereby　enhancing　the　TIN　loss　efficiency　(81.3%).　The　predominant　genus　was　Candidatus_Competibacter　(11.6%),　which　stored　COD　as　intracellular　carbon　source　and　performed　the　endogenous　denitrification.　The　SPNEDpr　process　provided　a　highly　efficient　and　economical　method　for　treating　urban　sewage.