In　this　work,　we　first　used　the　oil-phase　co-reduction　strategy　to　synthesize　the　RuxMny　(Mn/Ru　molar　ratio　(y/x)　=　7　:　20,　21　:　25,　and　17　:　10)　intermetallic　compounds,　then　used　the　KIT-6-templeting　method　to　prepare　mesoporous　titania　(meso-TiO2),　and　finally　used　the　impregnation　method　to　generate　the　RuxMny/meso-TiO2　(Ru　loading　=　0.60-0.79　wt%)　catalysts.　Various　techniques　were　used　to　measure　physicochemical　properties　of　the　samples,　and　their　catalytic　performance　was　determined　for　methyl　ethyl　ketone　(MEK)　oxidation.　It　is　found　that　the　RuxMny/meso-TiO2　samples　possessed　a　three-dimensionally　ordered　mesoporous　structure,　a　surface　area　of　71-173　m(2)/g,　and　a　uniform　RuxMny　particle　size　of　2.3-2.9　nm.　Among　all　of　the　samples,　Ru25Mn21/meso-TiO2　exhibited　the　best　catalytic　performance　and　good　hydrothermal　stability:　the　temperatures　at　MEK　conversions　of　10,　50,　and　90　%　were　131,　226,　and　248　degrees　C　at　a　space　velocity　of　20,000　mL/(g　h),　with　the　apparent　activation　energy,　specific　reaction　rate　at　160　degrees　C,　and　turnover　frequency　(TOF)　at　160　degrees　C　being　73　kJ/mol,　41.73　mmol/(g(Ru)　s),　and　4.20　s(-1),　respectively.　In　addition,　introduction　of　5　vol%　moisture　to　the　reaction　system　exerted　a　positive　effect　on　catalytic　activity　of　Ru/meso-TiO2　or　Ru25Mn21/meso-TiO2　at　higher　temperatures.　Such　good　performance　of　the　Ru25Mn21/meso-TiO2　sample　was　related　to　its　well　dispersed　Ru25Mn21　nanoparticles,　high　adsorbed　oxygen　species　concentration,　active　surface　lattice　oxygen,　high　MEK　adsorption　capacity,　good　redox　ability,　and　strong　interaction　between　Ru25Mn21　and　meso-TiO2.　We　propose　that　MEK　might　be　oxidized　by　the　adsorbed　oxygen　and/or　surface　lattice　oxygen　species　via　in　turn　formation　of　2,3-butanedione,　acetaldehyde,　acetic　acid,　formaldehyde,　and　formic　acid,　all　of　which　were　finally　converted　to　water　and　carbon　dioxide.