In　an　industrial　building,　heavy　equipment　can　be　configured　as　the　mass　of　multiple　tuned　mass　dampers　with　large　mass　ratio　(LMTMD)　without　the　addition　of　extra　mass.　This　paper　systematically　investigates　the　effects　of　the　LMTMD　for　the　mitigation　of　structural　seismic　responses　in　industrial　buildings　such　as　a　coal-fired　power　plant.　A　detailed　design　method　was　proposed　based　on　numerical　modeling,　optimization　of　the　key　parameters　and　evaluation　of　the　seismic　performance　of　the　structure.　Shaking　table　tests　were　conducted　on　a　scaled　model　and　time-history　analysis　were　performed　with　general　purpose　finite　element　program　ABAQUS.　The　coal-fired　power　plant　with　mass　irregularity　due　to　the　installation　of　heavy　coal　buckets　was　selected　as　the　sample　structure.　The　heavy　coal　buckets　are　utilized　as　the　mass　of　the　LMTMD.　The　feasibility　and　effectiveness　of　the　proposed　design　method　were　demonstrated　through　tests　and　analyses.　The　simulation　results　agree　well　with　the　test　results,　which　validate　the　accuracy　of　the　numerical　analyses　and　suggest　that　the　LMTMD　can　effectively　reduce　the　structural　dynamic　response　and　significantly　improve　the　seismic　performance　of　the　thermal　power　plant　structure.　The　reduction　rate　of　the　maximum　inter-story　drift　was　more　than　32.6%　under　earth-quake　excitations,　demonstrating　the　effectiveness　and　strong　robustness　of　the　LMTMD.　The　failure　mode　of　the　structure　was　optimized　by　the　reduced　damage　concentration.