Membrane　fouling　is　a　major　hurdle　impeding　real-world　application　of　membranes　for　advanced　wastewater　treatment.　In　this　study,　a　GO　membrane　and　a　reduced　GO　(rGO)　membrane　were　examined　in　parallel　for　their　anti-fouling　propensities　and　ability　to　remove　pharmaceutical　compounds　from　realistic　wastewater　effluents.　The　effects　of　membrane　properties　and　wastewater　characteristics　on　the　two　aspects　were　also　assessed　by　experiments　and　DFT　simulation.　The　results　showed　that　the　transmembrane　pressure　(TMP)　of　the　rGO　membrane　increased　by　0-3.5　kPa　after　filtering　a　secondary　wastewater　effluent　from　an　activated　sludge　system　(SW),　as　compared　to　201.6-292.1　kPa　for　the　GO　membrane.　Meanwhile,　slightly　greater　TMP　increases　were　observed　for　both　membranes　after　filtering　a　secondary　wastewater　effluent　from　a　partial　nitrification　and　denitrification　system　(PND),　but　the　fouling　remained　low　for　the　rGO　membrane.　Overall,　chemical　reduction　of　GO　to　rGO　led　to　larger　SSA　and　reduced　negative　charge,　which　promoted　adsorptive　filtration　of　pharmaceutical　compounds.　Also,　the　diminishing　of　functional　groups　possessed　by　the　GO　membrane　mitigated　attractive　interlayer　polar　interaction　and　expanded　membrane　pore　dimension,　thus　enhancing　the　permeability　and　anti-fouling　propensity　of　GO　membranes.