Single-mode　plasmonic　lasing　has　great　potential　for　use　in　photonic　and　sensing　applications.　In　this　work,　single-mode　lasing　is　realized　using　a　plasmonic-enhanced　woven　microfiber　that　shows　ultrahigh　sensitivity　to　the　ambient　environment.　This　plasmonic-enhanced　microfiber　is　fabricated　by　spraying　Ag　nanospheres　onto　rhodamine　6G-doped　polymer　microfibers.　Single-mode　laser　emission　with　an　ultranarrow　linewidth　(0.1　nm)　and　a　low　threshold　(18.8　kW/　mm(2))　is　achieved　in　the　microfiber　using　the　effects　of　mode　selection　and　plasmonic　enhancement　provided　by　the　Ag　nanospheres.　A　large　wavelength　shift　in　the　single-　limbic　enhan　mode　lasing　is　observed　when　the　proposed　laser　is　used　as　a　sensor　and　exposed　to　a　microfiber＇　humid　or　acidic　environment.　The　wavelength　shift　is　attributed　to　refractive　index　Textile　fiber　variations　in　the　microfiber　caused　by　either　moisture　absorption　or　chemical　reactions.　In　humidity　sensing,　the　laser＇s　sensitivity　is　as　high　as　826.6　pm/%　relative　humidity　(RH)　and　the　detection　limit　is　0.051%　RH.　An　innovative　strategy　for　acetic　acid　gas　sensing　is　proposed　that　uses　the　chemical　reaction　with　rhodamine　6G,　and　its　minimum　response　time　is　5　min.　Because　of　the　microfiber＇s　excellent　fabric　compatibility,　a　wearable　sensor　is　fabricated　by　weaving　the　plasmonic-enhanced　microfiber　into　clothes,　and　this　sensor　demonstrates　extreme　bending　stability.　The　results　reported　here　provide　a　novel　approach　to　the　design　and　fabrication　of　ultrasensitive　wearable　sensors　for　multifunctional　sensing　applications.