The　interaction　between　urban　river-canyon　topography　and　the　river-side　building　is　investigated　by　using　a　whole　analytic　model　of　a　semicircle　river-canyon　and　a　shear　wall　supported　by　a　semicircle　rigid　foundation　embedded　in　a　homogenous　half-space.　The　closed-form　analytical　solution　for　system　response　is　presented　based　on　the　wave　function　expansion　method.　The　analysis　focuses　on　the　effects　of　the　canyon-building　interaction　on　system　response.　The　strength　of　the　interaction　between　the　river-canyon　topography　and　the　building　changes　periodically　as　the　distance　between　the　canyon　and　the　structure　increases,　leading　to　the　interaction　having　beneficial　or　harmful　effects　on　the　building＇s　seismic　response.　The　foundation　peak　response　of　the　building　can　be　amplified　by　about　10%,　and　the　peak　of　the　building　relative　response　can　be　amplified　by　about　40%.　The　distribution　of　canyon-structure　spacing　with　strong　or　weak　interaction　is　closely　related　to　the　dynamic　characteristics　of　the　building　and　the　incident　angle　of　the　wave.　When　designing　buildings　along　the　river,　the　building　and　canyon　should　be　analyzed　as　a　whole　model　to　determine　whether　the　location　of　the　building　is　in　a　position　with　strong　interaction　with　the　river-canyon.　The　model　in　this　paper　may　be　useful　for　obtaining　insight　into　the　effects　of　canyon-structure　interaction　and　interpreting　the　observed　response　in　buildings　and　seismic　response　estimation　in　general.