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作者:

Kang, Wenjie (Kang, Wenjie.) | Lin, Lan (Lin, Lan.) | Zhang, Baiwen (Zhang, Baiwen.) | Shen, Xiaoqi (Shen, Xiaoqi.) | Wu, Shuicai (Wu, Shuicai.) (学者:吴水才)

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SCIE

摘要:

Alzheimer's Disease (AD) is a chronic neurodegenerative disease without effective medications or supplemental treatments. Thus, predicting AD progression is crucial for clinical practice and medical research. Due to limited neuroimaging data, two-dimensional convolutional neural networks (2D CNNs) have been commonly adopted to differentiate among cognitively normal subjects (CN), people with mild cognitive impairment (MCI), and AD patients. Therefore, this paper proposes an ensemble learning (EL) architecture based on 2D CNNs, using a multi model and multi-slice ensemble. First, the top 11 coronal slices of grey matter density maps for AD versus CN classifications were selected. Second, the discriminator of a generative adversarial network, VGG16, and ResNet50 were trained with the selected slices, and the majority voting scheme was used to merge the multi-slice decisions of each model. Afterwards, those three classifiers were used to construct an ensemble model. Multi-slice ensemble learning was designed to obtain spatial features, while multi-model integration reduced the prediction error rate. Finally, transfer learning was used in domain adaptation to refine those CNNs, moving them from working solely with AD versus CN classifications to being applicable to other tasks. This ensemble approach achieved accuracy values of 90.36%, 77.19%, and 72.36% when classifying AD versus CN, AD versus MCI, and MCI versus CN, respectively. Compared with other state-of-the-art 2D studies, the proposed approach provides an effective, accurate, automatic diagnosis along the AD continuum. This technique may enhance AD diagnostics when the sample size is limited.

关键词:

Alzheimer's disease Convolutional neural networks Deep learning Generative adversarial networks Mild cognitive impairment Structural MRI

作者机构:

  • [ 1 ] [Kang, Wenjie]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China
  • [ 2 ] [Lin, Lan]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China
  • [ 3 ] [Zhang, Baiwen]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China
  • [ 4 ] [Shen, Xiaoqi]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China
  • [ 5 ] [Wu, Shuicai]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China

通讯作者信息:

  • [Lin, Lan]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China

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来源 :

COMPUTERS IN BIOLOGY AND MEDICINE

ISSN: 0010-4825

年份: 2021

卷: 136

7 . 7 0 0

JCR@2022

ESI学科: COMPUTER SCIENCE;

ESI高被引阀值:11

被引次数:

WoS核心集被引频次: 62

SCOPUS被引频次: 78

ESI高被引论文在榜: 0 展开所有

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