Metagenomic　approach　was　applied　to　simultaneously　reveal　the　antibiotic　resistance　genes　(ARGs)　and　antibacterial　biocide　&　metal　resistance　genes　(BMRGs),　and　the　corresponding　microbial　hosts　with　high　mobility　during　aerobic　granular　sludge　(AGS)　formation　process.　The　results　showed　that　the　relative　abundance　of　BMRGs　was　88-123　times　that　of　ARGs.　AGS　process　was　easier　to　enrich　BMRGs,　leading　to　a　greater　risk　of　drug　resistance　caused　by　BMRGs　than　that　by　ARGs.　The　enrichments　of　ARGs　and　BMRGs　in　AGS　were　closely　related　to　several　enhanced　microbial　metabolisms　(i.e.,　cell　motility,　transposase　and　ATP-binding　cassette　transporters)　and　their　corresponding　regulatory　genes.　Several　enhanced　KEGG　Orthologs　(KO)　functions,　such　as　K01995,　K01996,　K01997　and　K02002,　might　cause　a　positive　impact　on　the　spread　of　ARGs　and　BMRGs,　and　the　main　contributors　were　the　largely　enriched　glycogens　accumulating　organisms.　The　first　dominant　ARGs　(adeF)　was　carried　by　lots　of　microbial　hosts,　which　might　be　enriched　and　propagated　mainly　through　horizontal　gene　transfer.　Candidatus　Competibacter　denitrificans　simultaneously　harbored　ARG　(cmx)　and　Cu　related　RGs　(corR).　Many　enriched　bacteria　contained　simultaneously　multiple　BMRGs　(copR　and　corR)　and　mobile　genetic　elements　(integrons　and　plasmids),　granting　them　high　mobility　capabilities　and　contributing　to　the　spread　of　BMRGs.　This　study　might　provide　deeper　understandings　of　the　proliferation　and　mobility　of　ARGs　and　BMRGs,　importantly,　highlighted　the　status　of　BMRGs,　which　laid　the　foundation　for　the　controlling　widespread　of　resistance　genes　in　AGS.