Spintronics　and　molecular　chemistry　have　achieved　remarkable　achievements　separately.　Their　combination　can　apply　the　superiority　of　molecular　diversity　to　intervene　or　manipulate　the　spin-related　properties.　It　inevitably　brings　in　a　new　type　of　functional　devices　with　a　molecular　interface,　which　has　become　an　emerging　field　in　information　storage　and　processing.　Normally,　spin　polarization　has　to　be　realized　by　magnetic　materials　as　manipulated　by　magnetic　fields.　Recently,　chiral-induced　spin　selectivity　(CISS)　was　discovered　surprisingly　that　non-magnetic　chiral　molecules　can　generate　spin　polarization　through　their　structural　chirality.　Here,　the　recent　progress　of　integrating　the　strengths　of　molecular　chemistry　and　spintronics　is　reviewed　by　introducing　the　experimental　results,　theoretical　models,　and　device　performances　of　the　CISS　effect.　Compared　to　normal　ferromagnetic　metals,　CISS　originating　from　a　chiral　structure　has　great　advantages　of　high　spin　polarization,　excellent　interface,　simple　preparation　process,　and　low　cost.　It　has　the　potential　to　obtain　high　efficiency　of　spin　injection　into　metals　and　semiconductors,　getting　rid　of　magnetic　fields　and　ferromagnetic　electrodes.　The　physical　mechanisms,　unique　advantages,　and　device　performances　of　CISS　are　sequentially　clarified,　revealing　important　issues　to　current　scientific　research　and　industrial　applications.　This　mini-review　points　out　a　key　technology　of　information　storage　for　future　spintronic　devices　without　magnetic　components.