Manganese-based　catalysts　show　a　tremendous　potential　in　propane　oxidation　due　to　their　low　cost　and　good　catalytic　activity　but　are　easily　deactivated　by　SO2.　In　this　work,　we　first　synthesized　the　mesoporous　sodium-doped　manganese　oxide　(meso-NaxMnOy)　using　the　mesoporous　silica　(KIT-6)　as　a　template　after　washing　with　a　concentrated　NaOH　aqueous　solution　and　then　prepared　the　platinum-cobalt　bimetallic　singleatom　(Pt1Co1/meso-NaxMnOy)　catalyst　using　the　polyvinyl　pyrrolidone-protecting　one-pot　strategy.　It　was　found　that　the　doping　of　13.8　wt　%　Na　dramatically　enhanced　the　SO2　tolerance　of　meso-NaxMnOy　but　inhibited　its　catalytic　activity　due　to　the　alkali　metal　poisoning.　Among　all　of　the　samples　for　the　oxidation　of　propane,　Pt1Co1/meso-NaxMnOy　showed　the　highest　catalytic　activity　(a　propane　conversion　of　90%　was　obtained　at　282　degrees　C　and　a　space　velocity　of　30　000　mL　g-1　h-1,　and　apparent　activation　energy,　specific　reaction　rate,　and　turnover　frequency　at　250　degrees　C　were　76.0　kJ　mol-1,　78.9　x　10-5　mol　gPt-1　h-1,　and　193.7　x　10-3　s-1,　respectively),　which　was　associated　with　the　Pt　and　Co　double　active　sites　with　good　dispersion,　abundant　electron　deficiency,　outstanding　lattice　oxygen　mobility,　good　low-temperature　reducibility,　and　large　capacity　and　weak　strength　of　propane　adsorption.　More　importantly,　the　Pt1Co1/meso-NaxMnOy　sample　possessed　the　excellent　resistance　to　sulfur　dioxide.　Propane　oxidation　occurred　via　different　reaction　routes　over　the　MnO2,　meso-NaxMnOy,　and　Pt1Co1/meso-NaxMnOy　samples,　with　the　Langmuir-　Hinshelwood　mechanism　being　dominated.　Propane　oxidation　over　Pt1Co1/meso-NaxMnOy　might　follow　a　pathway　of　propane　-＞　acetone　and　isopropoxide　-＞　carboxylate　and　fatty　ether　-＞　CO2　and　H2O.　Pt　and/or　Co　single　atoms　are　highly　dispersed　on　mesoNaxMnOy.　SO2　is　preferentially　adsorbed　at　the　Na　site　in　Pt1Co1/meso-NaxMnOy,　which　protects　the　active　Mn,　Pt,　and　Co　from　being　poisoned　by　SO2,　hence　making　Pt1Co1/meso-NaxMnOy　show　good　SO2　resistance　in　propane　oxidation.