Pt-based　catalysts　can　be　poisoned　by　the　chlorine　formed　during　the　oxidation　of　multicomponent　volatile　organic　compounds　(VOCs)　containing　chlorinated　VOCs.　Improving　the　low-temperature　chlorine　resistance　of　catalysts　is　important　for　industrial　applications,　although　it　is　yet　challenging.　We　hereby　demonstrate　the　essential　catalytic　roles　of　a　bifunctional　catalyst　with　an　atomic-scale　metal/oxide　interface　constructed　by　an　intermetallic　compound　nanocrystal.　Introducing　trichloroethylene　(TCE)　exhibits　a　less　negative　effect　on　the　catalytic　activity　of　the　bimetallic　catalyst　for　o-xylene　oxidation,　and　the　partial　deactivation　caused　by　TCE　addition　is　reversible,　suggesting　that　the　bimetallic,　HCl-etched　Pt3Sn(E)/CeO2　catalyst　possesses　much　stronger　chlorine　resistance　than　the　conventional　Pt/CeO2　catalyst.　On　the　site-isolated　Pt/Sn　catalyst,　the　presence　of　aromatic　hydrocarbon　significantly　inhibits　the　adsorption　strength　of　TCE,　resulting　in　excellent　catalytic　stability　in　the　oxidation　of　the　VOC　mixture.　Furthermore,　the　large　amount　of　surface　adsorbed　oxygen　species　generated　on　the　electronegative　Pt　is　highly　effective　for　low-temperature　C/Cl　bond　dissociation.　The　adjacent　promoter　(Sn/O)　possesses　the　functionality　of　acid　sites　to　provide　sufficient　protons　for　HCl　formation　over　the　bifunctional　catalyst,　which　is　considered　critical　to　maintaining　the　reactivity　of　Pt　by　removing　Cl　and　decreasing　the　polychlorinated　byproducts.