Background　and　Purpose　Understanding　the　pathogenesis　of　temporal　lobe　epilepsy　(TLE)　is　essential　for　its　diagnosis　and　treatment.　The　study　aimed　to　explore　regional　homogeneity　(ReHo)　and　changes　in　effective　connectivity　(EC)　between　brain　regions　in　TLE　patients,　hoping　to　discover　potential　abnormalities　in　certain　brain　regions　in　TLE　patients.　Methods　Resting-state　functional　magnetic　resonance　data　were　collected　from　23　TLE　patients　and　32　normal　controls　(NC).　ReHo　was　used　as　a　feature　of　multivariate　pattern　analysis　(MVPA)　to　explore　the　ability　of　its　alterations　in　identifying　TLE.　Based　on　the　results　of　the　MVPA,　certain　brain　regions　were　selected　as　seed　points　to　further　explore　alterations　in　EC　between　brain　regions　using　Granger　causality　analysis.　Results　MVPA　results　showed　that　the　classification　accuracy　for　the　TLE　and　NC　groups　was　87.27%,　and　the　right　posterior　cerebellum　lobe,　right　lingual　gyrus　(LING_R),　right　cuneus　(CUN_R),　and　left　superior　temporal　gyrus　(STG_L)　provided　significant　contributions.　Moreover,　the　EC　from　STG_L　to　right　fusiform　gyrus　(FFG_R)　and　LING_R　and　the　EC　from　CUN_R　to　the　right　occipital　superior　gyrus　(SOG_R)　and　right　occipital　middle　gyrus　(MOG_R)　were　altered　compared　to　the　NC　group.　Conclusion　The　MVPA　results　indicated　that　ReHo　abnormalities　in　brain　regions　may　be　an　important　feature　in　the　identification　of　TLE.　The　enhanced　EC　from　STG_L　to　FFG_R　and　LING_R　indicates　a　shift　in　language　processing　to　the　right　hemisphere,　and　the　weakened　EC　from　SOG_R　and　MOG_R　to　CUN_R　may　reveal　an　underlying　mechanism　of　TLE.