Effects　of　antibiotics　(azithromycin,　AZM,　1-40　mg/L)　and　quorum　sensing　inhibitor　(QSI,　2(5H)-furanone,　mg/L)　combined　pollution　with　environmental　concentration　of　copper　on　bacterial/archaeal　community　antibiotic　resistance　genes　(ARGs)　in　activated　sludge　system　were　explored.　QSI　inhibited　nitrification　obviously　than　AZM.　AZM　and　QSI　were　synergistic　inhibitions　on　bacterial　diversity,　and　AZM　inhibited　terial　compositions　more　than　QSI.　While,　QSI　had　more　impacts　on　archaeal　diversity/compositions.　Less　teractions　among　bacteria　and　archaea　communities　with　Aquimonas　as　keystone　genus.　Functional　differences　bacteria/archaea　communities　were　little,　and　AZM　had　more　effects　on　metabolism.　AZM　mainly　affected　trifying　bacteria　(Candidatus　Nitrospira　nitrificans　and　Nitrosomonas).　Specific　denitrifying　bacteria　were　enriched　by　AZM　(Brevundimonas,　1.76-31.69%)　and　QSI　(Comamonas,　0.61-9.61%),　respectively.　AZM　enriched　more　easily　than　QSI　and　they　were　antagonistic　to　proliferation　of　ARGs.　Bacteria　were　main　hosts　of　(macrolide-lincosamide-streptogramin　B,　other/efflux,　etc.)　and　archaea　(Methanosphaerula,　Methanolobus)　ried　multiple　ARGs.