The　illegal　usage　of　antibiotics　as　veterinary　drugs　is　an　increasing　threat　for　human　health.　The　specific　sensing　of　antibiotics　with　different　toxicity　levels　is　of　high　challenge,　and　mainly　relies　on　expensive,　time-consuming,　and　complex　instruments.　To　realize　specific　sensing　by　rapid　and　handy　optical　sensors,　a　metal-organic　framework　(MOF)　based　dual　sensor　system　is　herein　developed　using　two　MOF　materials　BUT-128　and　BUT-129　with　high　sensing　selectivity　and　sensitivity.　BUT-128　and　BUT-129　exhibit　the　lowest　limit　of　detection　(LOD)　towards　chloramphenicol　and　furazolidone　among　reported　MOF　sensors.　The　corresponding　dual　sensor　system　with　enriched　signal　readouts　realized　specific　sensing　of　the　strictly　forbidden　antibiotics　(chloramphenicol　and　nitrofurans)　from　other　regulated　veterinary　drugs　including　thiamphenicol,　a　structural　analog　of　chloramphenicol.　Besides,　the　strategy　of　this　work　is　expected　to　flourish　the　development　of　optical　sensors　with　high　specificity　for　environment　and　food　safety　purposes.