To　reduce　nitrogen　oxide　(NOx)　emission　from　diesel　engines　in　the　cold-start　process　benefitting　the　atmospheric　environment,　catalysts　with　superior　low-temperature　NOx　removal　efficiency　are　highly　demanded.　Herein,　we　report　an　efficient　Nb2O5/CuO/CeO2　(NbCuCe)　oxide　catalyst　for　the　selective　catalytic　reduction　(SCR)　of　NOx,　showing　much　higher　DeNO(x)　activity　below　200　degrees　C,　superior　sulfur　resistance,　faster　response,　and　much　less　NH3　slip　than　the　state-of-the-art　Cu-CHA　zeolite　catalyst.　Atomically　dispersed　Cu　species　facilitate　the　strong　interaction　between　Cu　and　the　Nb/Ce　base　catalyst,　which　significantly　improves　the　low-temperature　redox　properties　at　Cu-O-Ce　sites　and　NH3　adsorption/activation　at　Nb-O-Cu　sites,　thus　contributing　to　the　superior　SCR　performance　of　NbCuCe　at　low　temperatures.　The　developed　NbCuCe　catalyst　is　highly　promising　for　efficient　DeNO(x)　from　cold-start　diesel　engines　and　can　be　coupled　with　Cu-CHA　to　achieve　a　broad　operation　temperature　window.