To　reduce　the　thermal　deformation　of　ball　screws,　the　process　of　nano　coating　preparation　for　coating　on　ball　screws　to　reduce　temperature　rise　and　thereby　thermal　deformation　was　discussed　in　this　article.　Simultaneously,　the　cooling　mechanism　was　presented.　The　thermal　channels　and　the　relatively　even　distribution　of　graphene　in　the　nano　coating　were　observed　in　scanning　electron　microscopic　images.　In　terms　of　the　preparation　of　nano　coating,　optimization　design　was　carried　out　to　obtain　the　optimized　material　ratio　and　nozzle　flow　through　orthogonal　experiment.　The　influence　of　design　parameters　of　nano　coating　on　reducing　thermal　deformation　was　also　discussed.　The　experimental　results　show　that　the　maximum　temperature　rise,　thermal　deformation,　and　time　to　reach　thermal　balance　decreased　by　12.5,　69.1,　and　46.3%,　respectively.　The　effectiveness　of　nano　coating　in　reducing　thermal　deformation　was　validated　experimentally.