In　present　paper,　a　constant　flux　model　was　established　by　dividing　the　trans-membrane　pressure　(P)　into　the　partial　pressure　of　the　membrane　layer　(P-m)　(originating　from　the　pore　blocking/shrinking　resistance　of　the　membrane　and　the　inherent　membrane　resistance)　and　the　cake　layer　(P-c)　(originating　from　the　resistance　of　the　deposited　cake　layer)　in　constant　flux　dead-end　filtration　process　with　complex　fouling　mechanism.　The　pore　resistance　(R-p)　and　the　available　membrane　area　ratio　(A/A(0))　were　determinated　by　using　Hagen-Poiseuille　law.　In　addition,　the　variations　of　model　parameters　(K-m,　K-p,　K-c　and　K)　in　the　filtration　process　before　and　after　hydraulic/ultrasonic　cleaning　process　were　also　discussed.　Results　showed　that　the　model　predictions　had　good　agreements　with　experimental　data　at　different　conditions　by　using　Bovine　Serum　Albumin　(BSA)　(R-2　=0.99),　Humic　acid　(HA)　(R-2　=　0.99),　Sodium　Alginate　(SA)　solutions　(R-2　=0.99)　and　activated　sludge　(R-2　=0.99),　kaolin　(R-2　=0.99)　and　titanium　dioxide　suspensions　(R-2　=0.99).　Meanwhile,　the　available　membrane　area　ratio　decreased　in　the　initial　stage　(pore　blocking/shrinking　and　cake　filtration)　and　keep　constant　in　the　following　stage　(cake　filtration).　Moreover,　the　variation　of　available　membrane　area　ratio　before　and　after　hydraulic/ultrasonic　cleaning　process　can　be　give　a　guidance　to　optimize　the　membrane　cleaning　process.