In　heterogeneous　catalysis,　the　promotion　of　low　temperature　activity　and　enhancement　of　thermal　stability　simultaneously　especially　for　precious　metal　catalysts　is　always　highly　demanded　but　very　challenging.　Herein　we　report　a　novel　Pt　catalyst　on　ceria-alumina　(CeO2/Al2O3)　support　(Pt/CA-T)　engineered　by　a　two-step　ceria　deposition　strategy,　exhibiting　superior　thermal　stability　and　lowtemperature　carbon　monoxide　(CO)　oxidation　activity　after　activation.　Pt　single　sites　anchored　to　engineered　CeO2　edge　sites　are　much　more　stable　than　that　to　CeO2　(111)　surface,　and　such　stable　single　sites　can　be　transformed　into　highly　active　Pt　clusters　for　efficient　low-temperature　CO　oxidation.　Active　site　identification　indicates　that　the　CO　oxidation　activity　of　different　Pt　sites　follows　such　sequence:　Pt　cluster　step　sites　=　Pt　cluster　terrace　sites　＞　Pt　cluster　corner　sites　＞＞　Pt　single　sites　on　CeO2.　The　excellent　low　temperature　activity　of　activated　Pt/CA-T　catalyst　for　CO　oxidation　is　associated　with　its　abundant　Pt　cluster　step　and　terrace　sites　as　well　as　rich　Pt-CeO2　interfaces,　which　facilitate　the　adsorption　of　active　CO　species　and　superior　oxygen　activation/transfer　ability.　The　present　study　provides　new　insights　into　the　structure-activity　relationship　of　Pt-CeO2-Al2O3　catalyst,　which　can　also　guide　the　preparation　of　other　highly　robust　supported　catalysts　for　important　industrial　applications.　(c)　2021　Elsevier　Inc.　All　rights　reserved.