The　work　introduces　a　localized　surface　plasmon　resonance　(LSPR)　sensor　chip　integrated　with　vertical-cavity　surface-emitting　lasers　(VCSELs).　Using　VCSEL　as　the　light　source,　the　hexagonal　gold　nanoparticle　array　was　integrated　with　anodic　aluminum　oxide　(AAO)　as　the　mask　on　the　light-emitting　end　face.　The　sensitivity　sensing　test　of　the　refractive　index　solution　was　realized,　combined　with　microfluidic　technology.　At　the　same　time,　the　finite-difference　time-　domain　(FDTD)　algorithm　was　applied　to　model　and　simulate　the　gold　nanostructures.　The　experimental　results　showed　that　the　output　power　of　the　sensor　was　related　to　the　refractive　index　of　the　sucrose　solution.　The　maximum　sensitivity　of　the　sensor　was　1.65　x　10(6)　nW/RIU,　which　gives　it　great　application　potential　in　the　field　of　biomolecular　detection.