Brain　informatics　adopts　a　systematic　methodology　to　study　clinical　diagnosis　and　pathology　of　mental　disorders　from　macro,　meso　and　micro　points　of　view.　Systematic　studies　produce　multi-level　and　multi-aspect　health　big　data　of　mental　disorders.　Effectively　integrating　multi-level　mental　health　big　data　and　providing　multi-level　and　content-oriented　data　services　for　different　types　of　users　by　an　open　and　extendable　mode　becomes　new　requirements　on　the　acquisition　and　computing　of　mental　health　big　data.　The　existing　Data-Brain-based　brain　data　center　cannot　meet　these　new　requirements.　This　paper　proposes　a　brain　and　health　big　data　center　and　develops　a　content-oriented　cloud　service　architecture,　namely,　wisdom　as　a　service,　for　realizing　the　brain　and　health　big　data　center.　The　illustrative　example　demonstrates　significance　and　usefulness　of　the　proposed　approach.