In　this　study,　A-　and　B-site　doped　perovskite　La0.5Sr0.5Co0.8Ni0.2O3　LSCN)　was　prepared　by　sol-gel　method.　On　this　basis,　ZrO2　supported　LSCN　used　to　maintain　high　catalytic　activity　while　inhibit　the　leaching　of　toxic　Co　ions.　Compared　with　the　non-doped　LaCoO3,　the　ZrO2@La0.5Sr0.5Co0.8Ni0.2O3　(Z@LSCN82)/PMS　system　could　almost　completely　degrade　SMX　in　30　min.　In　addition,　the　leaching　amount　of　Co　ions　was　only　0.303　mg　L−1.　Free　radical　quenching　experiments　and　electron　paramagnetic　resonance　experiments　proved　that　active　species　SO4•−,　•OH　and　1O2　existed　in　the　Z@LSCN82/PMS　system,　and　SO4•−　played　a　major　role.　Besides,　the　catalyst　had　high　efficiency　for　SMX　degradation　in　a　wide　pH　range.　In　addition,　co-existing　anions　in　water　such　as　HPO4−　and　Cl−　also　showed　slight　inhibition　of　the　system.　It　was　indicated　that　the　Z@LSCN82/PMS　system　had　huge　potential　applications　for　practical　wastewater　treatment.　©　2022　Elsevier　Ltd