Bridges　may　suffer　large　residual　displacements　after　strong　earthquakes.　These　large　residual　displacements　may　increase　the　reinforcement　cost　and　even　lead　to　the　collapse　of　the　bridge.　Various　self-centering　energy　dissipation　braces　(SCEBs)　have　been　proposed　to　be　installed　to　the　frames　to　reduce　the　adverse　residual　displacement,　and　extensive　numerical　and　experimental　investigations　have　been　performed　to　examine　the　effectiveness　of　these　devices.　However,　previous　studies　mainly　focused　on　the　application　of　the　SCEB　to　the　steel　frames.　Very　limited　studies　investigated　the　seismic　performances　of　a　reinforced　concrete　(RC)　bridge　supported　by　the　two-column　bents　with　SCEBs.　This　paper　presents　numerical　studies　on　the　seismic　performances　of　an　RC　two-column　bent　bridge　equipped　with　SCEBs.　The　hysteretic　behavior　of　the　RC　two-column　bent　with　an　SCEB　is　firstly　modeled　and　validated　by　the　experimental　data.　The　bent　with　the　SCEB　model　is　then　applied　to　a　whole　bridge　to　calculate　seismic　responses　of　the　bridge.　The　influences　of　the　key　parameters　of　the　SCEB　on　the　seismic　responses　of　the　bridge　are　systematically　investigated　through　parametric　studies.　This　study　can　provide　an　insightful　basis　for　the　design　of　RC　two-column　bent　bridges　with　SCEBs　to　achieve　a　desirable　seismic　performance.　(C)　2020　American　Society　of　Civil　Engineers.