Background:　The　fractional　flow　reserve　(FFR)　is　the　gold　standard　used　to　diagnose　whether　coronary　stenosis　triggers　myocardial　ischemia.　Myocardial　ischemia　is　not　only　related　to　the　degree　of　coronary　artery　disease　but　also　to　hemodynamic　parameters　such　as　mean　arterial　pressure,　flow,　and　so　on.　This　paper　will　explore　the　effects　of　hemodynamic　parameters　on　FFR.　Methods:　Construct　an　ideal　vascular　model　of　moderately　stenosis　lesions　(40-70%)　with　different　hemodynamic　environments.　A　pressure　waveform　was　set　as　the　inlet　boundary,　a　microcirculation　resistance　in　the　hyperemia　state　was　set　as　the　outlet　boundary,　and　different　hemodynamic　environments　were　constructed　by　changing　the　mean　arterial　pressure　and　flow　at　rest.　The　microcirculation　resistance　in　the　resting　state　was　determined　by　the　mean　arterial　pressure　and　flow,　and　the　microcirculation　resistance　in　the　hyperemia　state　was　0.24　times　than　in　the　resting　state.　Results:　Flow　at　rest　was　found　to　have　the　greatest　impact　on　FFR,　followed　by　arterial　pressure.　Both　a　decrease　in　flow　and　an　increase　in　mean　arterial　pressure　caused　an　increase　in　the　FFR　value.　Conclusion:　Based　on　the　degree　of　stenosis　of　the　diseased　blood　vessel,　systolic　pressure,　diastolic　blood　pressure,　and　blood　flow　through　the　diseased　blood　vessel　in　the　resting　state,　a　preliminary　judgment　can　be　directly　made　as　to　whether　the　stenosis　causes　myocardial　ischemia.