This　paper　presented　an　experimental　study　on　the　seismic　performance　of　an　RC　frame　with　EPSC　latticed　concrete　infill　wall.　A　full-scale　single-bay　model　structure　were　designed　and　tested　on　a　shaking　table.　The　openings　in　the　walls　and　the　connection　type　between　the　walls　and　RC　frame　were　considered　in　the　test.　The　dynamic　characteristics,　acceleration　and　displacement　responses,　inter-story　shear　forces　and　strain　responses　were　analyzed.　The　test　results　indicate　that　the　designed　RC　frame　with　EPSC　latticed　concrete　infill　wall　has　satisfactory　seismic　performance.　A　great　number　of　cracks　are　clearly　observed　on　the　EPSC　and　several　concrete　lattice　columns　are　cracked　horizontally,　while　no　damage　is　found　on　the　RC　frame　under　continuous　strong　ground　motion.　The　latticed　concrete　walls　can　significantly　enhance　the　lateral　stiffness　of　the　RC　frame,　and　the　model　structure　undergoes　a　super-major　earthquake　with　minor　inter-story　drift　(only　1/513).　The　steel　bars,　designed　with　different　spacings　and　lengths,　can　play　an　effective　role　in　the　out-of-plane　stability　of　the　wall,　thus　improve　the　integrity　of　the　structural　system.　©　2020,　Editorial　Office　of　Journal　of　Building　Structures.　All　right　reserved.