Although　terahertz　metasurface-enabled　biosensors　focus　on　current　research,　reports　of　multidimensional　ultra　-sensitive　detection　in　the　terahertz　(THz)　regime　are　rare.　Here,　we　present　a　novel　flexible　THz　biosensor　that　consists　of　electromagnetic-induced　transparency-like　metasurfaces　and　patterned　graphene,　which　is　used　for　the　multidimensional　ultra-sensitive　detection　of　plant　protein.　Based　on　changes　in　frequencies　and　amplitude,　the　proposed　biosensor　could　detect　plant　protein　molecules　with　a　42.3　pg/ml　limit.　The　internal　mechanism　can　be　explained　by　the　positive　impact　of　plant　proteins　on　the　dielectric　environment.　As　plant　protein　con-centration　increases　and　covalent　bonding　of　the　patterned　graphene　strengthens,　the　Fermi　level　of　graphene　moves　to　the　Dirac　point,　and　the　conductivity　of　graphene　correspondingly　decreases.　As　a　result,　we　observed　marked　enhancement　of　the　transmission　amplitude　and　all　frequency　point　shifts.　We　also　show　results　for　fitting　the　coupled　harmonic　oscillator　model　and　theoretical　analysis　of　the　changes　of　graphene　Fermi　level　to　explain　the　sensing　mechanism.　In　addition,　we　successfully　achieved　biological-assisted　optical　modulation　amplification　under　laser　excitation.　This　work　may　provide　a　new　strategy　for　applying　terahertz　metasurfaces　in　the　field　of　biosensing.