y　The　prevalence　and　accumulation　of　antibiotic　resistance　genes　(ARGs)　were　frequently　detected　in　biological　wastewater　treatment　processes,　which　might　cause　potential　health　crisis　to　human.　In　present　study,　the　fates　of　ARGs　during　two　different　aerobic　granular　sludge　(AGS)　cultivation　processes　were　investigated.　The　results　showed　that　traditional　AGS　(T-AGS)　cultivation　process　and　enhanced　AGS　(E-AGS)　cultivation　process　had　significant　differences　(P　＜　0.005)　in　ARGs　shift　patterns.　E-AGS　process　had　higher　average　relative　abundance　(0.280　+/-　0.079)　of　ARGs　than　T-AGS　process　(0.130　+/-　0.041),　while　the　intensity　of　ARGs　enrichment　during　E-AGS　(1.52-5.29　fold)　was　lower　than　T-AGS　(3.79-75.31　fold)　process.　TnpA　and　intI1　as　two　different　types　of　mobile　genetic　elements　(MGEs)　carrying　ARGs,　were　observed　to　contribute　significantly　to　the　horizontal　gene　transfer　(HGT)　during　T-AGS　(r　=　0.902,　P　＜　0.050)　and　E-AGS　(r　=　0.823,　P　＜　0.001)　processes,　respectively.　Higher　HGT　level　took　place　and　more　possible　potential　hosts　(25　hosts)　harboring　ARGs　were　detected　during　E-AGS　process　comparing　with　T-AGS　process　(17　hosts).　Meanwhile,　over　large　AGS　might　increase　the　propagation　of　several　antibiotic　deactivation　ARGs,　so　it　was　not　advised.　Overall,　whether　during　T-AGS　or　during　E-AGS　process　which　was　applied　in　a　pilot-scale　sequencing　batch　reactor　treating　municipal　wastewater,　the　accumulation　and　spread　of　ARGs　were　inevitable.　It　should　be　valued　that　some　suitable　pretreatments　of　seed　sludge　should　be　executed,　meanwhile,　advanced　treatment　for　removing　of　ARGs　in　AGS　should　be　conducted　to　maintain　the　relative　abundances　of　ARGs　at　relatively　low　level.