In　this　work,　the　negative　differential　thermal　resistance　effect　has　been　proposed　in　a　solid-liquid-solid　sand-wiched　system　with　a　nanostructured　cold　surface.　Non-equilibrium　molecular　dynamics　simulations　demon-strate　that　the　heat　flux　in　the　present　sandwiched　system　increases　with　the　temperature　bias　for　low　temperature　bias,　while　for　high　temperature　bias,　the　heat　flux　decreases　counter-intuitively　with　increasing　temperature　bias.　Based　on　the　analysis　of　the　interfacial　thermal　resistance　and　the　density　depletion　length　at　the　solid-liquid　interface,　the　negative　differential　thermal　resistance　effect　at　high　temperature　bias　is　attributed　to　the　suppressed　solid-liquid　interfacial　thermal　conductance　with　decreasing　temperature.　In　addition,　it　is　found　that　the　negative　differential　thermal　resistance　effect　can　be　tuned　by　the　size　of　the　nanostructure.