Early　diagnosis　of　hepatic　inflammation　is　the　key　to　timely　treatment　and　avoid　the　worsening　of　liver　inflammation.　Near-infrared　fluorescence　(NIRF)　probes　have　high　sensitivity　but　low　spatial　resolution　in　lesion　imaging,　while　photoacoustic　(PA)　imaging　has　good　spatial　location　information.　Therefore,　the　development　of　a　NIRF/PA　dual-modal　probe　integrated　with　high　sensitivity　and　spatial　location　feedback　can　achieve　an　accurate　early　diagnosis　of　hepatic　inflammation.　Here,　we　report　an　activatable　NIRF/PA　dual-modal　probe　(hCy-Tf-CA)　for　the　detection　of　the　superoxide　anion　(O2　center　dot-)　in　early　hepatic　inflammation.　hCy-Tf-CA　showed　high　selectivity　and　sensitivity　for　detecting　O2　center　dot-　fluctuation　in　vitro.　More　importantly,　by　introducing　hepatocyte-targeting　cholic　acid　(CA),　the　probe　successfully　achieved　accurate　in　situ　imaging　of　acute　inflammatory　liver　injury　(AILI)　and　autoimmune　hepatitis　(AIH)　in　vivo.　The　introduced　CA　not　only　promotes　the　hepatic　targeting　accumulation　of　probes　but　also　improves　the　performance　of　low　background　dual-modal　imaging　in　vivo.　Therefore,　hCy-Tf-CA　provides　an　effective　strategy　for　significantly　improving　in　situ　imaging　performance　and　holds　great　potential　for　early,　sensitive,　and　accurate　diagnosis　of　hepatic　inflammation.