An　anti-seismic　and　energy-efficient　structure,　namely　assembled　lightweight　concrete　filled　steel　tubular　(CFST)　frame　infilled　with　composite　wall,　is　proposed.　In　order　to　investigate　the　combining　effect　of　assembled　lightweight　CFST　frames　with　composite　walls,　three　full-scale　assembled　lightweight　CFST　frames　infilled　with　composite　walls　and　one　full-scale　assembled　lightweight　CFST　frame　under　low　cyclic　lateral　load　were　tested.　Composite　walls　included　a　wall　without　opening,　a　wall　with　opening　of　window　and　a　wall　with　opening　of　door.　The　strength,　stiffness,　ductility,　hysteretic　behavior　and　energy　dissipation　of　the　specimens　were　compared　and　investigated.　The　combining　effect　of　composite　wall　and　assembled　lightweight　CFST　frame　was　analyzed.　A　practical　method　for　estimating　the　lateral　strength　of　such　structure　was　proposed.　The　results　show　that　the　combining　effect　of　composite　wall　and　assembled　lightweight　CFST　frame　is　well　if　the　composite　wall　is　effectively　connected　with　the　frame.　The　assembled　lightweight　CFST　frame　infilled　with　composite　wall　has　higher　ultimate　strength,　better　energy-dissipation　capacity,　faster　stiffness　degeneration　and　better　ductility　comparing　with　the　assembled　lightweight　CFST　hollow　frame.　The　area　and　classification　of　openings　have　a　great　impact　on　the　structural　behavior.　The　openings　of　window　and　door　reduce　the　bearing　capacity　and　initial　stiffness　but　have　little　influence　on　the　cumulative　energy　dissipation　of　structure.　The　proposed　practical　calculating　method　can　evaluate　the　lateral　ultimate　strength　of　such　structure　favorably.　©　2019,　Editorial　Office　of　Journal　of　Building　Structures.　All　right　reserved.