In　an　asymmetric　multi-core　architecture,　multiple　heterogeneous　cores　share　the　last-level　cache　(LLC).　Due　to　the　different　memory　access　requirements　among　heterogeneous　cores,　the　LLC　competition　is　more　intense.　In　the　current　work,　we　propose　a　heterogeneity-aware　replacement　policy　for　the　partitioned　cache　(HAPC),　which　reduces　the　mutual　interference　between　cores　through　cache　partitioning,　and　tracks　the　shared　reuse　state　of　each　cache　block　within　the　partition　at　runtime　to　guide　the　replacement　policy　to　keep　cache　blocks　shared　by　multiple　cores　in　multithreaded　programs.　In　the　process　of　updating　the　reuse　state,　considering　the　difference　of　memory　accesses　to　LLC　by　heterogeneous　cores,　the　cache　replacement　policy　tends　to　keep　cache　blocks　required　by　big　cores,　to　better　improve　the　LLC　access　efficiency　of　big　cores.　Compared　with　LRU　and　the　SRCP,　which　are　the　state-of-the-art　cache　replacement　algorithms,　the　performance　of　big　cores　can　be　significantly　improved　by　HAPC　when　running　multithreaded　programs,　while　the　impact　on　little　cores　is　almost　negligible,　thus　improving　the　overall　performance　of　the　system.