The　demand　for　isopropyl　alcohol　(IPA)　has　increased　significantly　due　to　its　excellent　disinfection　and　sterili-zation　effect.　The　production　of　IPA　by　isopropyl　acetate　(IPAC)　with　methanol　(MeOH)　transesterification　is　limited　by　chemical　equilibrium,　and　there　are　three　binary　azeotropic　mixtures　in　the　system,　which　makes　the　production　process　more　complex　and　energy　consumption　higher.　Thus,　the　reaction　distillation　(RD)　process　is　designed　and　developed　for　producing　IPA　more　effectively　and　economically.　The　KRD001　as　the　commercial　catalyst　is　utilized　to　build　the　kinetic　reaction　model,　which　supplemented　the　primary　data　of　the　chemical　industry.　The　Pilot-scale　RD　experiments　for　producing　IPA　are　explored　to　verify　the　feasibility　of　RD　and　the　reliability　of　the　model　and　to　ensure　the　establishment　of　the　follow-up　process.　The　hybrid　distillation　process　(RDC-HDC)　of　RD　combining　pressure-swing　distillation　(PSD)　is　designed　and　optimized　based　on　the　pressure　sensitivity　analysis　and　sequential　iterative　optimization　algorithm　on　the　minimum　TAC　under　the　2,800　tons　annual　output　of　the　factory.　The　thermal　coupling　processes　(RDWC-HDC　and　RDWC-RDC)　are　explored　to　find　energy-saving　schemes.　The　RDWC-HDC　process　can　reduce　20.46%　in　energy　consumption,　save　25.65%　in　total　annual　cost　(TAC),　and　reduce　annually　the　1834.73　tons　and　9557.13　$　in　CO2　emissions,　55.20　tons　and　20.59　$　in　SO2　emissions　and　27.60　tons,　and　20.56　$　in　NOx　emissions　in　contrast　with　the　RDC-HDC　process,　respectively.　The　exergy　destruction　elaborates　that　the　RDWC-HDC　process　is　positive　for　energy　saving.　The　RDWC-HDC　process　is　the　most　economical　and　attractive　for　producing　IPA　through　the　energy,　economy,　environment,　and　exergy　(4E)　analyses.