Laser　Powder　Bed　Fusion　(LPBF)　is　considered　as　one　of　the　most　current　additive　manufacturing　technologies　that　could　prepare　customized　and　complex　parts.　There　have　been　challenges　for　LPBF-fabricating　2xxx　(Al-Cu)　alloy　because　that　own　alloy　elements　cause　large　solidification　ranges　and　hot　cracking　is　susceptible　to　generate　during　solidification.　In　this　study,　a　crack-free　and　high-strength　Al-Cu-Mg-Mn-Zr　alloy　was　designed　and　manufactured　by　LPBF.　The　results　showed　that　the　laser　energy　density　has　an　important　effect　on　microstructure　and　density,　and　it　was　sufficient　to　melt　the　alloy　powder　and　deliver　high-quality　builds　at　333　J/　mm3.　The　microhardness,　tensile　strength,　and　yield　strength　of　the　LPBF-fabricated　Al-Cu-Mg-Mn-Zr　alloy　increased　with　increasing　laser　energy　density.　In　addition,　the　tensile　fracture　surfaces　exhibited　mixed　brittle　and　ductile　fracture　features　at　low　energy　density　values　(231-358J/mm3).　The　ductile　fracture　was　observed　at　higher　energy　density　values　(＞463J/mm3).　When　the　laser　density　was　set　at　500　J/mm3,　the　LPBF-fabricated　alloy　exhibited　high　relative　density　(99.88%)　and　the　most　optimal　mechanical　properties,　with　microhardness　of　141.5　Hv,　tensile　strength　of　343.9　MPa,　yield　strength　of　311.0　MPa,　and　elongation　of　6.1%.　After　solution　treatment　at　560　degrees　C　for　2　h　and　water　quenching,　the　Al-Cu-Mg-Mn-Zr　alloy　exhibits　the　excellent　mechanical　properties　with　ultimate　tensile　strength　of　483.6　MPa,　yield　strength　of　365.5　MPa,　and　elongation　of　13.4%.