Pressure　and　Temperature　Swing　Adsorption　(PTSA)　is　an　appealing　purification　technology　for　removing　low　CO2　concentration　from　confined　space　potentially.　In　this　work,　a　systematic　method　integrating　dynamic　process　simulation,　sensitivity　analysis,　process　optimization,　and　energy　consumption　assessment　was　established　to　investigate　a　PTSA　process　of　low　CO2　concentration　separation　in　the　confined　space　using　two　adsorbents　(Zeolite　13X　and　NaUSY).　The　dual　site　Langmuir　adsorption　isothermal　models　of　N-2　and　CO2　were　established,　and　calculated　results　showed　good　agreement　with　the　experimental　data.　After　parametric　sensitivity　analysis,　key　operational　parameters　(i.e.　adsorption　pressure,　desorption　pressure,　regeneration　temperature　and　P/F　ratio)　were　optimized　to　achieve　minimum　process　energy　consumption.　Those　results　indicated　that　Zeolite　13X　was　a　good　candidate　for　separating　low　concentration　CO2　from　confined　space　with　lower　energy　consumption　(55.03　kJ.Nm(-3)　N-2).　The　simulation　result　can　provide　a　novel　strategy　for　removing　low　CO2　concentration　from　confined　space.