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Author:

Luo, Jiajun (Luo, Jiajun.) | Zhao, Shudong (Zhao, Shudong.) | Gao, Xiangsheng (Gao, Xiangsheng.) | Varma, Swastina Nath (Varma, Swastina Nath.) | Xu, Wei (Xu, Wei.) | Tamaddon, Maryam (Tamaddon, Maryam.) | Thorogate, Richard (Thorogate, Richard.) | Yu, Haoran (Yu, Haoran.) | Lu, Xin (Lu, Xin.) | Salmeron-Sanchez, Manuel (Salmeron-Sanchez, Manuel.) | Liu, Chaozong (Liu, Chaozong.)

Indexed by:

EI Scopus SCIE

Abstract:

Nanotopography is an effective method to regulate cells' behaviors to improve Ti orthopaedic implants' in vivo performance. However, the mechanism underlying cellular matrix-nanotopography interactions that allows the modulation of cell adhesion has remained elusive. In this study, we have developed novel nanotopographic features on Ti substrates and studied human osteoblast (HOb) adhesion on nanotopographies to reveal the interactive mechanism regulating cell adhesion and spreading. Through nanoflat, nanoconvex, and nanoconcave TiO2 nanotopographies, the evolution of Coulomb's force between the extracellular matrix and nanotopographies has been estimated and comparatively analyzed, along with the assessment of cellular responses of HOb. We show that HObs exhibited greater adhesion and spreading on nanoconvex surfaces where they formed super matured focal adhesions and an ordered actin cytoskeleton. It also demonstrated that Coulomb's force on nanoconvex features exhibits a more intense and concentrated evolution than that of nanoconcave features, which may result in a high dense distribution of fibronectin. Thus, this work is meaningful for novel Ti-based orthopaedic implants' surface designs for enhancing their in vivo performance.

Keyword:

cell adhesion Ti implant protein adsorption nanotopography cell-material interaction

Author Community:

  • [ 1 ] [Luo, Jiajun]Univ Coll London, Div Surg & Intervent Sci, Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, England
  • [ 2 ] [Zhao, Shudong]Univ Coll London, Div Surg & Intervent Sci, Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, England
  • [ 3 ] [Gao, Xiangsheng]Univ Coll London, Div Surg & Intervent Sci, Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, England
  • [ 4 ] [Varma, Swastina Nath]Univ Coll London, Div Surg & Intervent Sci, Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, England
  • [ 5 ] [Xu, Wei]Univ Coll London, Div Surg & Intervent Sci, Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, England
  • [ 6 ] [Tamaddon, Maryam]Univ Coll London, Div Surg & Intervent Sci, Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, England
  • [ 7 ] [Liu, Chaozong]Univ Coll London, Div Surg & Intervent Sci, Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, England
  • [ 8 ] [Luo, Jiajun]Univ Glasgow, Ctr Cellular Microenvironm, Glasgow G12 8LT, Scotland
  • [ 9 ] [Salmeron-Sanchez, Manuel]Univ Glasgow, Ctr Cellular Microenvironm, Glasgow G12 8LT, Scotland
  • [ 10 ] [Zhao, Shudong]Beihang Univ, Key Lab Biomech & Mechanobiol, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn,Minist Educ, Beijing 100083, Peoples R China
  • [ 11 ] [Gao, Xiangsheng]Beijing Univ Technol, Beijing Key Lab Adv Mfg Technol, Fac Mat & Mfg, Beijing 100124, Peoples R China
  • [ 12 ] [Xu, Wei]Univ Sci & Technol Beijing, Beijing Adv Innovat Ctr Mat Genome Engn, Inst Adv Mat & Technol, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China
  • [ 13 ] [Lu, Xin]Univ Sci & Technol Beijing, Beijing Adv Innovat Ctr Mat Genome Engn, Inst Adv Mat & Technol, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China
  • [ 14 ] [Thorogate, Richard]UCL, London Ctr Nanotechnol, London WC1H 0AH, England
  • [ 15 ] [Yu, Haoran]Zhejiang Univ, Inst Bioengn, Coll Chem & Biol Engn, Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 310027, Peoples R China

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Source :

ACS APPLIED MATERIALS & INTERFACES

ISSN: 1944-8244

Year: 2022

9 . 5

JCR@2022

9 . 5 0 0

JCR@2022

ESI Discipline: MATERIALS SCIENCE;

ESI HC Threshold:66

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 8

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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