A Fast Current Sensing Front-End IC Design for Nanopore-Based DNA Sequencing - 文章详情页

作者：

Liu, Xu (Liu, Xu.) | Fan, Qiumeng (Fan, Qiumeng.) | Hu, Xin (Hu, Xin.) | Wan, Peiyuan (Wan, Peiyuan.) | Chen, Zhijie (Chen, Zhijie.)

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摘要：

This　paper　presents　a　fast　sensing　front-end　integrated　circuit　for　nanopore-based　DNA　sequencing.　Single-stranded　DNA　passes　through　the　nanopore　on　the　cell　membrane　to　generate　an　ultra-small　current　on　the　electrodes.　Therefore,　a　trans-impedance　amplifier　and　a　voltage-to-time　conversion　circuit　are　designed　and　optimized　in　this　work　to　realize　the　current　detection.　This　front-end　IC　reduces　the　single　base　detection　time　to　10μs　at　minimum.　The　whole　circuit　is　implemented　in　180-nm　CMOS　process.　The　results　show　that　the　implemented　IC　can　detect　the　minimum　current　of　10　pA　and　can　measure　the　current　through　nanopores　ranging　from　10　pA　to　150　pA.　Its　power　consumption　is　42.8μW,　and　the　input　reference　noise　of　the　input　stage　is　1.93　pV2/Hz.　©　2022　IEEE.

关键词：

Nanopores Timing circuits Integrated circuit design DNA sequences Integrated circuits DNA Comparator circuits Gene encoding Comparators (optical)

作者机构：

[ 1 ] [Liu, Xu]Beijing University of Technology, Faculty of Information Technology, Beijing, China
[ 2 ] [Fan, Qiumeng]Beijing University of Technology, Faculty of Information Technology, Beijing, China
[ 3 ] [Hu, Xin]School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, China
[ 4 ] [Wan, Peiyuan]Beijing University of Technology, Faculty of Information Technology, Beijing, China
[ 5 ] [Chen, Zhijie]Beijing University of Technology, Faculty of Information Technology, Beijing, China

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