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Author:

Liu, Xu (Liu, Xu.) | Fan, Qiumeng (Fan, Qiumeng.) | Hu, Xin (Hu, Xin.) | Wan, Peiyuan (Wan, Peiyuan.) | Chen, Zhijie (Chen, Zhijie.)

Indexed by:

EI Scopus

Abstract:

This paper presents a fast sensing front-end integrated circuit for nanopore-based DNA sequencing. Single-stranded DNA passes through the nanopore on the cell membrane to generate an ultra-small current on the electrodes. Therefore, a trans-impedance amplifier and a voltage-to-time conversion circuit are designed and optimized in this work to realize the current detection. This front-end IC reduces the single base detection time to 10μs at minimum. The whole circuit is implemented in 180-nm CMOS process. The results show that the implemented IC can detect the minimum current of 10 pA and can measure the current through nanopores ranging from 10 pA to 150 pA. Its power consumption is 42.8μW, and the input reference noise of the input stage is 1.93 pV2/Hz. © 2022 IEEE.

Keyword:

Nanopores Timing circuits Integrated circuit design DNA sequences Integrated circuits DNA Comparator circuits Gene encoding Comparators (optical)

Author Community:

  • [ 1 ] [Liu, Xu]Beijing University of Technology, Faculty of Information Technology, Beijing, China
  • [ 2 ] [Fan, Qiumeng]Beijing University of Technology, Faculty of Information Technology, Beijing, China
  • [ 3 ] [Hu, Xin]School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, China
  • [ 4 ] [Wan, Peiyuan]Beijing University of Technology, Faculty of Information Technology, Beijing, China
  • [ 5 ] [Chen, Zhijie]Beijing University of Technology, Faculty of Information Technology, Beijing, China

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Source :

ISSN: 2163-5048

Year: 2022

Volume: 2022-December

Page: 81-85

Language: English

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 2

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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