Aerodynamic　loading　of　wind　turbines　can　be　divided　into　aerodynamic　damping　and　dynamic　loading　which　have　damping　effect　and　dynamic　effect　on　the　seismic　response　of　structures,　respectively.　A　theoretical　model　is　set　up　for　analyzing　the　regularities　and　mechanism　of　how　operating　conditions　affect　the　seismic　response　of　wind　turbine　considering　the　running　and　parked　conditions.　The　dynamic　response　of　wind　turbines　is　analyzed　using　FAST　software　under　different　wind-earthquake　combinations　for　NREL　baseline　5　MW　wind　turbines　to　validate　the　findings　obtained　in　the　theoretical　model.　The　effects　of　input　earthquake　direction　on　the　seismic　response　of　wind　turbines　are　analyzed.　The　results　show　that　the　effect　of　operating　condition　on　the　dynamic　response　of　wind　turbines　depends　on　the　seismic　amplitude　and　wind　speed.　The　most　unfavorable　load　combination　is　seismic　excitation　in　parked　condition　under　strong　ground　motions.　When　the　seismic　action　is　weaker,　it　is　the　rated　wind　speed-design　seismic　action　combination.　The　incident　angle　of　earthquake　waves　significantly　affects　the　dynamic　response　of　wind　turbines.　©　2019,　Engineering　Mechanics　Press.　All　right　reserved.