To　promote　the　application　of　steel-concrete　composite　columns　in　mega　column　structures　of　super　high-rise　buildings,　the　key　seismic　technology　and　application　of　steel　reinforced　concrete　(SRC)　and　concrete　filled　steel　tube　(CFT)　columns　are　reviewed　on　the　basis　of　a　brief　introduction　of　the　mega　frame　structure　with　steel-concrete　composite　mega　columns.　Several　technical　issues　on　the　steel-concrete　composite　mega　columns　that　need　to　be　further　investigated　are　proposed.　Research　shows　that　the　mega　frame　structure　is　an　effective　anti-seismic　system,　with　perfect　mechanical　property.　The　finished　and　ongoing　super　high-rise　buildings　mostly　utilize　the　mega　frame　structure　with　steel-concrete　composite　mega　columns　in　China.　Related　studies　mostly　focuse　on　elastic-plastic　analysis　and　shaking　table　test.　The　complex　cross-sectional　steel-concrete　composite　mega　columns　have　good　seismic　performance　after　reasonable　design.　The　related　mechanical　behavior　theoretical　calculation　method　with　universality　and　the　reasonable　structural　constructions　are　the　key　technical　issues　that　urgently　need　to　be　further　studied.　©　2019,　Editorial　Board　of　Journal　of　Harbin　Institute　of　Technology.　All　right　reserved.