Direct,　convenient,　and　sensitive　monitoring　of　the　residues　of　multiple　drugs　in　complex　environments　is　important　but　remains　a　challenge.　Here,　we　report　a　surface-enhanced　Raman　scattering　(SERS)-based　multi-plexed　lateral　flow　immunoassay　(LFA)　that　supports　the　simultaneous　and　sensitive　detection　of　commonly　used　drugs　kanamycin,　ractopamine,　clenbuterol,　and　chloramphenicol　in　unprocessed　complex　samples　through　the　dual　signal　amplification　strategy　of　numerous　efficient　hotspots　and　magnetic　enrichment.　Multilayered　magnetic-core　dual-shell　nanoparticles　(MDAu@Ag)　with　controllable　subtle　nanogaps　were　fabricated　via　the　polyethyleneimine-mediated　layer-by-layer　(LBL)　assembly　of　two　layers　of　Au@Ag　satellites　onto　super　-paramagnetic　Fe3O4　cores　and　conjugated　with　specific　antibodies　as　multifunctional　tags　in　the　LFA　system　for　rapid　capture,　separation,　and　quantitative　analysis.　Two　Raman　reporters　were　embedded　in　internal　nanogaps　and　modified　on　the　surface　of　MDAu@Ag　for　the　simultaneous　and　ultrasensitive　detection　of　four　targets　on　two　test　lines,　which　greatly　simplified　the　fabrication　and　signal　reading　of　SERS-LFA.　The　proposed　assay　can　rapidly　detect　multiple　drug　residues　in　35　min　with　detection　limits　down　to　pg/mL　level.　Moreover,　the　MDAu@Ag-based　SERS-LFA　demonstrated　better　stability,　higher　throughput,　and　superior　sensitivity　(at　least　400　times)　than　traditional　colloidal　gold　immunochromatography,　showing　its　great　potential　in　the　field　of　point-of-care　testing.