Using　artificial　water,　the　simultaneous　partial　nitrification,　ANAMMOX　(anaerobic　ammonium　oxidation),　and　denitrification　(SNAD)　granular　sludge　process　was　started　in　a　sequencing　batch　reactor　(SBR),　and　then　the　ammonia　concentration　in　the　influent　was　reduced　gradually.　After　stable　operation　for　a　period　of　time　under　the　low　ammonia　concentration,　sewage　treated　by　a　pre-precipitation　process　was　used　as　a　substrate　to　investigate　the　performance　and　stability　of　the　SNAD　granular　sludge　process.　The　results　show　that　after　the　SNAD　process　was　successfully　started,　the　ammonia　removal　rate　was　greater　than　98%,　and　total　the　nitrogen　removal　rate　was　about　89%.　As　the　influent　ammonia　concentration　decreased,　the　nitride-oxidizing　bacteria　(NOB)　activity　was　increased　and　the　total　nitrogen　removal　rate　gradually　decreased　to　75%.　When　the　pre-precipitated　domestic　sewage　(NH4+-N　52-63　mg•L-1,　COD　99-123　mg•L-1)　was　used　as　the　inflow,　the　average　effluent　removal　rate　of　the　total　effluent　was　73.2%,　the　effluent　COD　concentration　was　below　35　mg•L-1,　and　the　maximum　effluent　ammonia　nitrogen　and　total　nitrogen　concentration　were　0.7　mg•L-1　and　12.8　mg•L-1.　The　ammonia　and　total　nitrogen　concentration　in　the　continuous　30　day　effluent　reached　the　1A　level　of　the　integrated　discharge　standard　of　water　pollutants　for　municipal　wastewater　treatment,　indicating　that　the　removal　of　organics　and　nitrogen　from　domestic　sewage　was　achieved　efficiently　and　synchronously.　©　2019,　Science　Press.　All　right　reserved.