It　is　very　important　to　establish　a　life　prediction　model　that　evaluates　the　combined　high　and　low　cycle　fatigue　(CCF)　damage　of　materials.　Based　on　the　toughness　exhaustion,　this　paper　develops　a　CCF　life　prediction　model　considering　loading　interaction　effect.　The　loading　interaction　factor　is　proposed　to　reflect　the　interaction　effect　between　high　cycle　fatigue　and　low　cycle　fatigue.　The　proposed　model　does　not　require　any　additional　material　parameters　and　is　convenient　for　application.　The　experimental　data　of　four　materials　including　GH4033　Ni-basis　alloy,　TC11　titanium　alloy,　LY12-CZ　aluminum　alloy,　and　45　steel　are　applied　to　verify　the　proposed　model.　Comparing　the　prediction　results　of　the　proposed　model　with　the　Miner＇s　rule　and　the　T-K　model,　the　results　show　that　the　predicted　results　of　the　proposed　model　are　more　satisfactory.