• 综合
  • 标题
  • 关键词
  • 摘要
  • 学者
  • 期刊-刊名
  • 期刊-ISSN
  • 会议名称
搜索

作者:

Xue, Qingxin (Xue, Qingxin.) | Ren, Xiaoyu (Ren, Xiaoyu.) | Gao, Bin (Gao, Bin.) | Li, Shu (Li, Shu.) | Song, Zhiming (Song, Zhiming.) | Ding, Jinli (Ding, Jinli.) | Chang, Yu (Chang, Yu.)

收录:

EI Scopus SCIE

摘要:

Extracorporeal membrane oxygenation (ECMO) is a life support system used in the treatment of severe respiratory and circulatory failure. High shear stress caused by the high rotational speed of centrifugal blood pumps can cause hemolysis and platelet activation, which are among the major factors leading to the complications of the ECMO system. In this study, a novel blood pump named rotary displacement blood pump (RDBP), which can considerably reduce rotational speed and shear stress while ensuring the normal pressure flow relationship, was proposed. We employed computational fluid dynamics (CFD) analysis to investigate the performance of RDBP under adult ECMO support operating conditions (5 L/min with 350 mmHg). The efficiency and H-Q curves of the RDBP were calculated to evaluate its hydraulic performance, and pressure, flow patterns, and shear stress distribution were analyzed to estimate the hemodynamic characteristics in the pump. In addition, the modified index of hemolysis (MIH) was calculated for the RDBP based on a Eulerian approach. The hydraulic efficiency of the RDBP was 47.28%. The velocity distribution of flow field in the pump was relatively uniform. Most of the liquid (more than 75%) in the pump was exposed to low scale shear stress (<1 Pa), which was close to normal physiological conditions. The gap area was the main distribution location of high scale shear stress. The high wall shear stress (>9 Pa) volume fraction of the RDBP was small and located in the boundary areas between the rotor's edge and the housing. The MIH value of the RDBP was 9.87 +/- 0.93 (mean +/- SD). The RDBP can achieve better hydraulic efficiency and hemodynamic performance at lower rotational speed. The design of this novel pump is expected to provide a new direction for developing a blood pump for ECMO.

关键词:

rotary displacement blood pump blood pump CFD ECMO hemodynamics

作者机构:

  • [ 1 ] [Xue, Qingxin]Beijing Univ Technol, Fac Environm & Life, Beijing 100124, Peoples R China
  • [ 2 ] [Ren, Xiaoyu]Beijing Univ Technol, Fac Environm & Life, Beijing 100124, Peoples R China
  • [ 3 ] [Gao, Bin]Beijing Univ Technol, Fac Environm & Life, Beijing 100124, Peoples R China
  • [ 4 ] [Li, Shu]Inst Med Device Control, Natl Inst Food & Drug Control, Beijing, Peoples R China
  • [ 5 ] [Song, Zhiming]Tongji Univ, Shanghai East Hosp, Dept Cardiac Surg, Sch Med, Shanghai, Peoples R China
  • [ 6 ] [Ding, Jinli]Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China
  • [ 7 ] [Chang, Yu]Zhejiang Univ, Natl Clin Res Ctr Child Hlth, Sch Med, Childrens Hosp, Hangzhou, Peoples R China

通讯作者信息:

  • [Gao, Bin]Beijing Univ Technol, Fac Environm & Life, Beijing 100124, Peoples R China;;

电子邮件地址:

查看成果更多字段

相关关键词:

来源 :

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING

ISSN: 2040-7939

年份: 2023

期: 6

卷: 39

2 . 1 0 0

JCR@2022

ESI学科: COMPUTER SCIENCE;

ESI高被引阀值:19

被引次数:

WoS核心集被引频次:

SCOPUS被引频次: 1

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

近30日浏览量: 0

归属院系:

在线人数/总访问数:532/4995524
地址:北京工业大学图书馆(北京市朝阳区平乐园100号 邮编:100124) 联系我们:010-67392185
版权所有:北京工业大学图书馆 站点建设与维护:北京爱琴海乐之技术有限公司