This　paper　aims　to　investigate　the　buckling　behaviors　of　cold-formed　steel　(CFS)　channels　with　slotted　web　holes　determined　by　the　Steel　Stud　Manufacturers　Association　(SSMA)　under　eccentric　compression,　and　propose　the　simplified　direct　strength　method　(DSM)　formulas　for　engineering　practicing.　An　experimental　study　on　20　specimens　was　conducted,　including　18　slotted　perforated　specimens　with　nine　eccentricities　increasing　from-20　mm　to　20　mm　and　2　unperforated　specimens　subjected　to　axial　compression.　Two　kinds　of　nominal　lip　lengths　for　cross　sections　were　selected　as　15　mm　and　20　mm.　The　experimental　results　indicated　that　the　failure　modes　of　slotted　perforated　specimens　subjected　to　eccentric　compression　depended　on　the　position　of　the　ec-centricity.　Compared　with　the　slotted　perforated　specimens　subjected　to　pure　axial　compression,　the　ultimate　loads　of　specimens　subjected　to　positive　eccentric　compression　decreased　by　21.70　%　on　average,　while　they　decreased　by　16.38　%　on　average　for　those　subjected　to　negative　eccentric　compression.　Moreover,　a　nonlinear　elasto-plastic　finite　element　model　(FEM)　was　developed　and　validated　against　the　experimental　results.　Furthermore,　combined　with　the　experimental　results,　extensive　FE　parametric　analyses　were　conducted　to　predict　the　eccentricity　impact　coefficient　formulas.　Finally,　based　on　DSM　of　unperforated　CFS　members　sub-jected　to　pure　axial　compression　in　AISI　S100-16　and　the　eccentricity　impact　coefficient　formulas,　the　suitable　DSM　design　formulas　for　slotted　perforated　CFS　channels　determined　by　the　SSMA　under　eccentric　compression　were　proposed,　without　the　need　to　calculate　the　elastic　buckling　critical　stress　for　slotted　perforated　CFS　channels.