The　distribution　of　active　sites　across　the　surface　of　a　catalyst　can　help　alleviate　issues　with　mass　transfer　and　improve　atom　economy.　To　create　such　a　precise　catalyst,　this　work　reports　the　high　loading　of　a　single　metal　(tungsten/nickel)　atom　oxide　anchored　on　the　surface　of　TiO2　nanoparticles　(WNiTiR)　through　a　simple　sonication　method.　According　to　aberration-corrected　high-angle　annular　dark-field　scanning　transmission　electron　microscopy　(HAADF-STEM),　tungsten/nickel　atoms　are　distributed　uniformly　over　TiO2　and　reduced　graphene　oxide　(rGO).　The　photodegradation　process　was　optimized　by　investigating　the　impact　of　different　catalysts,　dosage　variations,　and　the　pH　of　the　reaction　medium.　Remarkably,　the　WNiTiR　nanocomposites　demonstrated　increased　photocatalytic　activity　by　degrading　over　97.15%　of　Ibuprofen　(IBF)　and　98.35%　of　Ciprofloxacin　(CF)　pollutants.　The　findings　of　the　experiment　on　reactive　oxygen　species　(ROS)　showed　that　the　predominant　active　species　were　superoxide　radicals　(O2　center　dot-).　In　addition,　the　WNiTiR　nanocomposite　displayed　superior　structural　stability　and　reusability　even　after　being　put　through　six　cycles　of　continuous　use.