The　nanoparticles　have　substantial　uses　in　the　treatment　of　several　diseases　and　in　drug　delivery　systems　and　the　nanoparticles　are　injected　in　the　base　fluid　which　is　transported　in　the　cardiovascular　system　on　the　mechanism　of　peristalsis.　This　study　highlights　the　Casson　hybrid　nanofluid　thermal　inspection　with　blood　base　fluid.　The　copper　and　iron　oxide　nanoparticles　are　used　to　assess　the　hybrid　nanofluid　characteristics.　The　conduit　for　the　present　analysis　is　considered　non-uniform　complex　wavy　and　curved.　The　base　fluid　is　considered　as　a　Casson　fluid　which　reports　the　shear　thinning　and　thickening　consequences　of　blood　base　liquid.　The　fundamental　conservation　laws　are　utilized　to　model　the　flow　problem　and　simplified　under　the　assumption　of　long　wave-length　and　creeping　transport.　The　shooting　method　is　used　to　compute　the　different　flow　and　heat　transfer　characteristics　The　impact　of　various　interesting　parameters　is　examined　graphically.