Progressive　collapse　is　a　nonlinear　dynamic　behavior　of　structure　systems.　The　key　issue　in　establishing　the　simplified　method　for　the　practical　engineering　design　is　to　evaluate　the　dynamic　effect　accurately.　To　investigate　the　dynamic　progressive　collapse　mechanism　and　the　dynamic　effect　of　reinforced　concrete　substructures,　one　static　and　four　dynamic　experiments　were　conducted　on　four　specimens,　which　had　the　identical　dimensions　and　material　properties.　The　results　indicated　that　the　stress　concentration　and　asymmetric　deformation　in　the　dynamic　tests　were　severer　than　those　in　the　static　test　due　to　the　high　strain　rate　effect.　Thus,　the　cracks　developed　intensively　at　the　beam　ends　and　the　concrete　spalling　area　caused　by　compression　was　relatively　small　in　dynamic　tests.　The　general　dynamic　resistance,　in　which　the　effects　of　dynamic　damage　and　high　strain　rate　to　the　structural　resistance　were　inherently　considered,　was　able　to　accurately　predict　the　resistance　demand　in　the　real　progressive　collapse　process.　In　addition,　the　dynamic　amplification　effect　was　enhanced　by　the　effect　of　dynamic　damage　and　high　strain　rate,　thus　the　practical　dynamic　amplification　factors　were　larger　than　the　predicted　values　of　the　conventional　theory.　©　2019,　Engineering　Mechanics　Press.　All　right　reserved.