This　study　proposes　a　probabilistic　performance　evaluation　framework　for　sea-crossing　cable-stayed　bridges　(SCBs)　subjected　to　wind　and　wave　excitations　with　the　incorporation　of　wind　speed　and　direction,　bridge　orientation,　wind-wave　correlation　and　parameter　uncertainties.　Both　the　bridge　serviceability　and　safety　are　taken　into　account　in　the　performance　assessment.　The　fragility　analysis　of　the　SCB　under　wind　and　wave　loads　is　conducted　using　the　wind-wave　correlation　model　constructed　based　on　field　data.　The　actual　damage　proba-bility　of　a　local　SCB　is　computed　by　combining　the　fragilities　of　bridge　under　different　wind　incidence　angles　with　the　copula-based　joint　probability　distribution　(JPD)　of　wind　speed　and　direction,　which　is　developed　using　the　wind　field　data　recorded　in　Lianyungang　city　of　China　from　1971　to　2020.　The　results　show　that　under　the　defined　wind　incidence　angle　of　0　degrees,　the　exemplar　SCB　suffers　the　highest　fragility.　Moreover,　with　the　data-based　occurrence　probability　model　of　wind　and　wave　hazards,　the　damage　probabilities　under　all　possible　wind　speeds　and　directions　are　computed;　then　the　optimal　and　most　unfavorable　orientations　of　the　SCB　are　obtained.　This　investigation　provides　a　comprehensive　and　practical　method　for　the　performance　evaluation　and　design　opti-mization　of　SCBs　under　wind　and　wave　loads　with　long-term　recorded　hazard　data　at　the　local　site.