A　novel　aerobic　denitrifying　bacterium　capable　of　quorum　quenching　(QQ),　Acinetobacter　strain　WZL728,　was　first　isolated.　WZL728　showed　excellent　aerobic　denitrification　performance　and　QQ　activity.　Besides,　its　optimal　aerobic　denitrification　condition　was　pH　7.1,　temperature　32.0.　C,　C/N　ratio　7.4　and　shaking　speed　108.0　rpm.　However,　its　optimal　QQ　condition　was　pH　7.2,　temperature　32.4.C,　C/N　ratio　7.1　and　shaking　speed　96.1　rpm.　The　QQ　activity　of　WZL728　was　more　tolerant　to　environmental　changes　than　its　aerobic　denitrification　performance　because　of　the　different　response　of　its　denitrification　and　QQ　function　genes　expression.　Moreover,　it　was　revealed　that　the　strain　degraded　N-acyl-homoserine　lactones　(AHLs)　with　long　acyl　chains　by　secreting　extracellular　QQ　acylase.　Due　to　the　high　QQ　activity　of　the　aerobic　denitrifying　bacterium,　it　may　have　great　potential　for　controlling　membrane　biofouling　in　the　field　of　wastewater　treatment.　(c)　2022　The　Author(s).　Published　by　Elsevier　B.V.　This　is　an　open　access　article　under　the　CC　BY-NC-ND　license　(http://creativecommons.org/licenses/by-nc-　nd/4.0/).