Hydrogen　peroxide　(H2O2)　electrogenerated　via　two-electron　oxygen　reduction　reaction　at　cathode　plays　an　important　role　in　electrochemical　advanced　oxidation　processes　for　organic　pollutants　removal　from　wastewater.　Herein,　multi-walled　carbon　nanotubes　and　carbon　black　co-modified　graphite　felt　electrode　(MWCNTs-CB/GF)　was　prepared　as　an　efficient　cathode　for　H2O2　electrogeneration　and　amoxicillin　removal　by　anodic　oxidation　with　hydrogen　peroxide　(AO-H2O2)　and　electro-Fenton　(EF)　under　mild　pH　condition.　Besides,　the　physicochemical　and　electrochemical　properties　of　MWCNTs-CB/GF　were　characterized　by　scanning　electron　microscopy,　N-2　adsorption　and　desorption　experiment,　contact　angle　measurement,　X-ray　photoelectron　spectroscopy,　and　linear　sweep　voltammetry.　Compared　with　GF,　MWCNTs-CB/GF　showed　a　higher　H2O2　generation　of　309.0　mg　L-1　with　a　current　efficiency　of　60.9%　(after　120　min)　and　more　effective　amoxicillin　removal　efficiencies　of　97.5%　(after　120　min)　and　98.7%　(after　30　min)　in　AO-H2O2　and　EF　(with　0.5　mM　Fe2+)　processes,　under　the　condition　of　current　density　12　mA　cm(-2)　and　initial　pH　5.5.　Meanwhile,　the　TOC　removal　efficiency　was　45.2%　during　EF　process　after　120　min.　Anodic　oxidation,　H2O2　oxidation,　and　methanol　capture　indicated　that　center　dot　OH　generated　via　electro-activation　reaction　at　MWCNTs-CB/GF　and　Fenton　reaction　in　solution　played　the　dominant　role　in　amoxicillin　removal.　Moreover,　the　TOC　removal　was　associated　with　center　dot　OH　generated　during　Fenton　reaction　in　the　solution.　The　major　intermediates　of　AMX　degradation　by　EF　process　were　identified　using　LC-MS　and　the　possible　degradation　pathways　were　proposed　containing　of　beta-lactam　ring　opening,　hydroxylation　reaction,　decarboxylation　reaction,　methyl　groups　in　the　thiazolidine　ring　oxidation　reaction,　bond　cleavage,　and　rearrangement　processes.　All　of　the　above　results　proved　that　MWCNTs-CB/GF　was　an　excellent　cathode　for　AMX　degradation　under　mild　pH　condition.